Output

Carotid Plaque Macrophage Burden and Inflammatory Lipid-Associated Macrophage Markers Predict Secondary Major Adverse Cardiovascular Events after Endarterectomy

Koen Prange, G. Bel-Bordes, Marie Depuydt,  P. Barlampas, Moritz Reif,  M.L.B. Grönloh, R.W.M. Kempkes, G. Griffith, C. van Roomen, Y.Y. Zhu, A. Edsfeldt, J. Sun, M.J.M. de Jong, B.M. Mol, Bram Slütter, Ilze Bot, Anette Neele, D.P.V. de Kleijn, G.J. de Borst, Jeffrey Kroon, A. Wezel, H. Smeets, Erik Stroes, Jaap van Buul, Pieter Goossens, Johan Kuiper, Isabel Goncalves, Gerard Pasterkamp, Michal Mokry, Menno de Winther

European Heart Journal 2026

Protein carbamylation in atherosclerotic plaques correlates with uremia and disease progression, localizing predominantly to foam cells

Valeria Saar-Kovrov, Aleksandra Pawlowska, Adrien Guillot, Marion JJ Gijbels, Judith C Sluimer, Lieve Temmerman, Pieter Goossens, Barend ME Mees, Frank Tacke, Vera Jankowski, Joachim Jankowski, Marjo MPC Donners, Erik AL Biessen 

Frontiers in Immunology 2025

Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis

Isabeau Vermeulen, Mengying Li, Hester van Mourik, Tulasi Yadati, Gert Eijkel, Benjamin Balluff, Roger Godschalk, Lieve Temmerman, Erik A L Biessen, Aditya Kulkarni, Jan Theys, Tom Houben, Berta Cillero-Pastor, Ronit Shiri-Sverdlov 

FEBS Journal 2025

Macrophage heterogeneity in atherosclerosis: A matter of context

Elias B Wieland, Laura JAP Kempen, Marjo MPC Donners, Erik AL Biessen, Pieter Goossens 

European journal of immunology 2024

Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage‐specific Fas‐induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics

Indira Medina, Elias B Wieland, Lieve Temmerman, Jeroen JT Otten, Beatriz Bermudez, Ilze Bot, Timo Rademakers, Erwin Wijnands, Leon Schurgers, Barend Mees, Theo JC van Berkel, Pieter Goossens, Erik AL Biessen 

European Journal of Immunology 2024

Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability

Han Jin, Cheng Zhang, Jan Nagenborg, Peter Juhasz, Adele V Ruder, Cornelis JJM Sikkink, Barend ME Mees, Olivia Waring, Judith C Sluimer, Dietbert Neumann, Pieter Goossens, Marjo MPC Donners, Adil Mardinoglu, Erik AL Biessen 

Cardiovascular Diabetology 2024

Spatial metabolomics identifies LPC (18: 0) and LPA (18: 1) in advanced atheroma with translation to plasma for cardiovascular risk estimation

Jianhua Cao, Marta Martin-Lorenzo, Kim van Kuijk, Elias B Wieland, Marion J Gijbels, Britt SR Claes, Angeles Heredero, Gonzalo Aldamiz-Echevarria, Ron MA Heeren, Pieter Goossens, Judith C Sluimer, Benjamin Balluff, Gloria Alvarez-Llamas 

Arteriosclerosis, Thrombosis, and Vascular Biology 2024

Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients

Chang Lu, Marjo MPC Donners, Julius BJ de Baaij, Han Jin, Jeroen JT Otten, Marco Manca, Anton Jan van Zonneveld, J Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Barend Mees, Judith C Sluimer, Rachel Cavill, Joël MH Karel, Pieter Goossens, Erik AL Biessen 

Frontiers in Immunology 2024

In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

Anette Christ, Sanne L Maas, Han Jin, Chang Lu, Bart Legein, Erwin Wijnands, Lieve Temmerman, Jeroen Otten, Aaron Isaacs, Martin Zenke, Monika Stoll, Erik A L Biessen, Emiel P C van der Vorst

Free Radical Biol Med 2024

Protocol for multispectral imaging on cryosections to map myeloid cell heterogeneity in its spatial context

Elias B Wieland, Laura JAP Kempen, Chang Lu, Marjo MPC Donners, Erik AL Biessen, Pieter Goossens 

STAR protocols  2023

Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients

Chang Lu, Marjo MPC Donners, Joël Karel, Hetty de Boer, Anton Jan van Zonneveld, Hester den Ruijter, J Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Rachel Cavill, Javier Perales-Patón, Ele Ferrannini, Pieter Goossens, Erik AL Biessen 

Atherosclerosis  2023

GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis

Jan Nagenborg, Han Jin, Adele V Ruder, Lieve Temmerman, Barend Mees, Casper Schalkwijk, Daniel Müller-Klieser, Thorsten Berg, Pieter Goossens, Marjo MPC Donners, Erik AL Biessen 

Frontiers in Immunology  2023

Monocyte heterogeneity in cardiovascular disease

Adele V Ruder, Suzan MW Wetzels, Lieve Temmerman, Erik AL Biessen, Pieter Goossens 

Cardiovascular research  2023

Culture density influences the functional phenotype of human macrophages

Adele V Ruder, Lieve Temmerman, Joep MA van Dommelen, Jan Nagenborg, Chang Lu, Judith C Sluimer, Pieter Goossens, Erik AL Biessen 

Frontiers in Immunology  2023

Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol

Kim van Kuijk, Ian R McCracken, Renée JHA Tillie, Sebastiaan EJ Asselberghs, Dlzar A Kheder, Stan Muitjens, Han Jin, Richard S Taylor, Ruud Wichers Schreur, Christoph Kuppe, Ross Dobie, Prakesh Ramachandran, Marion J Gijbels, Lieve Temmerman, Phoebe M Kirkwoord, Joris Luyten, Yanming Li, Heidi Noels, Pieter Goossens, John R Wilson-Kanamori, Leon J Schurgers, Ying H Shen, Barend ME Mees, Erik AL Biessen, Neil C Henderson, Rafael Kramann, Andrew H Baker, Judith C Sluimer 

Cardiovascular research  2023

Blood milieu in acute myocardial infarction reprograms human macrophages for trauma repair

Margaux A C Fontaine, Han Jin, Mick Gagliardi, Mat Rousch, Erwin Wijnands, Monika Stoll, Xiaofei Li, Leon Schurgers, Chris Reutelingsperger, Casper Schalkwijk, Nynke M S van den Akker, Daniel G M Molin, Lars Gullestad, Jan Eritsland, Pavel Hoffman, Mona Skjelland, Geir Ø Andersen, Pål Aukrust, Joël Karel, Evgueni Smirnov, Bente Halvorsen, Lieve Temmerman, Erik A L Biessen

Adv Sci (Weinh) 2023

Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice

Emiel PC van der Vorst, Sanne L Maas, Kosta Theodorou, Linsey JF Peters, Han Jin, Timo Rademakers, Marion J Gijbels, Mat Rousch, Yvonne Jansen, Christian Weber, Michael Lehrke, Corinna Lebherz, Daniela Yildiz, Andreas Ludwig, Jacob F Bentzon, Erik AL Biessen, Marjo MPC Donners 

Frontiers in Cardiovascular Medicine 2023

Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context

Pieter Goossens, Chang Lu, Jianhua Cao, Marion J Gijbels, Joël MH Karel, Erwin Wijnands, Britt SR Claes, Gregorio E Fazzi, Tim FE Hendriks, Kristiaan Wouters, Evgueni Smirnov, Marc JM van Zandvoort, Benjamin Balluff, Eva Cuypers, Marjo MPC Donners, Ron MA Heeren, Erik AL Biessen 

Cell metabolism 2022

Low density lipoprotein exposure of plasmacytoid dendritic cells blunts toll-like receptor 7/9 signaling via NUR77

Anette Christ, Pieter G Goossens, Erwin Wijnands, Han Jin, Bart Legein, Tammy Oth, Aaron Isaacs, Monika Stoll, Joris Vanderlocht, Esther Lutgens, Mat JAP Daemen, Martin Zenke, Erik AL Biessen 

Biomedicines 2022

Two-faced Janus: the dual role of macrophages in atherosclerotic calcification

Olivia J Waring, Nikolaos T Skenteris, Erik AL Biessen, Marjo MPC Donners 

Cardiovascular research 2022

Integrative multiomics analysis of human atherosclerosis reveals a serum response factor‐driven network associated with intraplaque hemorrhage

Han Jin, Pieter Goossens, Peter Juhasz, Wouter Eijgelaar, Marco Manca, Joël MH Karel, Evgueni Smirnov, Cornelis JJM Sikkink, Barend ME Mees, Olivia Waring, Kim van Kuijk, Gregorio E Fazzi, Marion JJ Gijbels, Martina Kutmon, Chris TA Evelo, Ulf Hedin, Mat JAP Daemen, Judith C Sluimer, Ljubica Matic, Erik AL Biessen 

Clinical and Translational Medicine 2021

PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

Hannah Wilkinson, Hugh Leonard, Daxin Chen, Toby Lawrence, Michael Robson, Pieter Goossens, John H McVey, Anthony Dorling 

Iscience 2021

Shedding of klotho: functional implications in chronic kidney disease and associated vascular disease

Valeria Saar-Kovrov, Marjo MPC Donners, Emiel PC Van der Vorst 

Frontiers in Cardiovascular Medicine 2021

Atheroma-Specific Lipids in ldlr–/– and apoe–/– Mice Using 2D and 3D Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Jianhua Cao, Pieter Goossens, Marta Martin-Lorenzo, Frédéric Dewez, Britt SR Claes, Erik AL Biessen, Ron MA Heeren, Benjamin Balluff 

Journal of the American Society for Mass Spectrometry 2020

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension

Danielle Kerkhofs, Britt T van Hagen, Irina V Milanova, Kimberly J Schell, Helma van Essen, Erwin Wijnands, Pieter Goossens, W Matthijs Blankesteijn, Thomas Unger, Jos Prickaerts, Erik A Biessen, Robert J van Oostenbrugge, Sébastien Foulquier 

Theranostics 2020

Membrane cholesterol efflux drives tumor-associated macrophage reprogramming and tumor progression 

Pieter Goossens, Juan Rodriguez-Vita, Anders Etzerodt, Marion Masse, Olivia Rastoin, Victoire Gouirand, Thomas Ulas, Olympia Papantonopoulou, Miranda Van Eck, Nathalie Auphan-Anezin, Magali Bebien, Christophe Verthuy, Thien Phong Vu Manh, Martin Turner, Marc Dalod, Joachim L Schultze, Toby Lawrence 

Cell metabolism 2019

Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment

Jan Nagenborg, Pieter Goossens, Erik AL Biessen, Marjo MPC Donners 

European journal of pharmacology 2017

High-density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-κB/STAT1-IRF1 signaling

Emiel PC van Der Vorst, Kosta Theodorou, Yongzheng Wu, Marten A Hoeksema, Pieter Goossens, Christina A Bursill, Taghi Aliyev, Leonie FA Huitema, Sander W Tas, Ine MJ Wolfs, Marijke JE Kuijpers, Marion J Gijbels, Casper G Schalkwijk, Debby PY Koonen, Shahla Abdollahi-Roodsaz, Kimberly McDaniels, Chih-Chieh Wang, Michael Leitges, Toby Lawrence, Jogchum Plat, Miranda Van Eck, Kerry-Anne Rye, Lhousseine Touqui, Menno PJ De Winther, Erik AL Biessen, Marjo MPC Donners 

Cell metabolism 2017